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- Title
Rationale for targeting pepsin in the treatment of reflux disease.
- Authors
Johnston, Nikki; Wells, Clive W; Samuels, Tina L; Blumin, Joel H
- Abstract
We undertook to (1) obtain unequivocal evidence to confirm or rebut our initial observations that pepsin is taken up by hypopharyngeal epithelial cells by receptor-mediated endocytosis, (2) investigate whether uptake of pepsin at pH 7, in nonacidic refluxate, is of pathological significance, and 3) test our hypothesis that inactive but stable pepsin (<pH 8) taken up by hypopharyngeal epithelial cells causes damage by becoming reactivated inside the cell.
- Publication
The Annals of otology, rhinology, and laryngology, 2010, Vol 119, Issue 8, p547
- ISSN
0003-4894
- Publication type
Journal Article
- DOI
10.1177/000348941011900808