We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Characterizing DNA methylation alterations from The Cancer Genome Atlas.
- Authors
Weisenberger, Daniel J
- Abstract
The Cancer Genome Atlas (TCGA) Research Network is an ambitious multi-institutional consortium effort aimed at characterizing sequence, copy number, gene (mRNA) expression, microRNA expression, and DNA methylation alterations in 30 cancer types. TCGA data have become an extraordinary resource for basic, translational, and clinical researchers and have the potential to shape cancer diagnostic and treatment strategies. DNA methylation changes are integral to all aspects of cancer genomics and have been shown to have important associations with gene expression, sequence, and copy number changes. This Review highlights the knowledge gained from DNA methylation alterations in human cancers from TCGA.
- Publication
The Journal of clinical investigation, 2014, Vol 124, Issue 1, p17
- ISSN
1558-8238
- Publication type
Journal Article
- DOI
10.1172/JCI69740