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- Title
B4 androgen ablation: attacking the prostate cancer stem cell.
- Authors
Wicha, Max S
- Abstract
There is increasing evidence that prostate cancers in rodent models and in men contain a cellular subpopulation that displays stem cell properties. These prostate cancer stem cells (PCSCs) lack androgen receptor expression and are increased in castration-resistant disease. In this issue of the JCI, a study from Yoshioka et al. demonstrates that PCSCs are regulated by a pathway in which α6β4 integrin amplifies signaling through ErbB2 and c-Met receptors. Targeting this pathway provides a novel therapeutic strategy for hormone refractory prostate cancer.
- Publication
The Journal of clinical investigation, 2013, Vol 123, Issue 2, p563
- ISSN
1558-8238
- Publication type
Journal Article
- DOI
10.1172/JCI67460