We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Epidermal Langerhans cells tune skin reactivity to contact allergens.
- Authors
Udey, Mark C
- Abstract
Allergic contact dermatitis is a common disorder that has fascinated dermatologists and immunologists for decades. Extensive studies of contact sensitivity reactions in mice established a mechanistic paradigm that has been revisited in recent years, and the involvement of Langerhans cells (LCs), a population of epidermal dendritic cells, in immune responses to epicutaneously applied antigens has been questioned. In this issue of the JCI, Gomez de Agüero et al. describe an elegant series of experiments that implicate LCs in tolerance induction, positioning these cells as key regulators of immunologic barrier function.
- Publication
The Journal of clinical investigation, 2012, Vol 122, Issue 5, p1602
- ISSN
1558-8238
- Publication type
Journal Article
- DOI
10.1172/JCI63190