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- Title
Adipose tissue remodeling and obesity.
- Authors
Kai Sun; Kusminski, Christine M.; Scherer, Philipp E.; Sun, Kai
- Abstract
To fulfill its role as the major energy-storing tissue, adipose has several unique properties that cannot be seen in any other organ, including an almost unlimited capacity to expand in a non-transformed state. As such, the tissue requires potent mechanisms to remodel, acutely and chronically. Adipocytes can rapidly reach the diffusional limit of oxygen during growth; hypoxia is therefore an early determinant that limits healthy expansion. Proper expansion requires a highly coordinated response among many different cell types, including endothelial precursor cells, immune cells, and preadipocytes. There are therefore remarkable similarities between adipose expansion and growth of solid tumors, a phenomenon that presents both an opportunity and a challenge, since pharmacological interventions supporting healthy adipose tissue adaptation can also facilitate tumor growth.
- Publication
Journal of Clinical Investigation, 2011, Vol 121, Issue 6, p2094
- ISSN
0021-9738
- Publication type
Academic Journal
- DOI
10.1172/JCI45887