We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pain as a channelopathy.
- Authors
Raouf, Ramin; Quick, Kathryn; Wood, John N
- Abstract
Mendelian heritable pain disorders have provided insights into human pain mechanisms and suggested new analgesic drug targets. Interestingly, many of the heritable monogenic pain disorders have been mapped to mutations in genes encoding ion channels. Studies in transgenic mice have also implicated many ion channels in damage sensing and pain modulation. It seems likely that aberrant peripheral or central ion channel activity underlies or initiates many pathological pain conditions. Understanding the mechanistic basis of ion channel malfunction in terms of trafficking, localization, biophysics, and consequences for neurotransmission is a potential route to new pain therapies.
- Publication
The Journal of clinical investigation, 2010, Vol 120, Issue 11, p3745
- ISSN
1558-8238
- Publication type
Journal Article
- DOI
10.1172/JCI43158