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- Title
IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection.
- Authors
Alter, Galit; Kavanagh, Daniel; Rihn, Suzannah; Luteijn, Rutger; Brooks, David; Oldstone, Michael; van Lunzen, Jan; Altfeld, Marcus
- Abstract
Persistent levels of IL-10 play a central role in progressive immune dysfunction associated with chronic viral infections such as HIV, but the underlying mechanisms are poorly understood. Because IL-10 affects the phenotypic and functional properties of DCs, which are responsible for initiating adaptive immune responses, we investigated whether IL-10 induces changes in DC phenotype and function in the context of HIV infection. Here, we show that IL-10 treatment of immature and mature human DCs in culture induced contrasting phenotypic changes in these populations: immature DCs exhibited aberrant resistance to NK cell-mediated elimination, whereas mature DCs exhibited increased susceptibility to NKG2D-dependent NK elimination. Treatment of immature and mature DCs with HIV resulted in potent IL-10 secretion and the same phenotypic and functional changes observed in the IL-10-treated cells. Consistent with these in vitro data, LNs isolated from individuals infected with HIV exhibited aberrant accumulation of a partially "immature" DC population. Together, these data suggest that the progressive immune dysfunction observed in chronic viral infections might be caused in part by IL-10-induced reversal of DC susceptibility to NK cell-mediated elimination, resulting in the accumulation of poorly immunogenic DCs in LNs, the sites of adaptive immune response induction.
- Publication
The Journal of clinical investigation, 2010, Vol 120, Issue 6, p1905
- ISSN
1558-8238
- Publication type
Journal Article
- DOI
10.1172/JCI40913