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- Title
IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani.
- Authors
Pitta, Maira G R; Romano, Audrey; Cabantous, Sandrine; Henri, Sandrine; Hammad, Awad; Kouriba, Bouréma; Argiro, Laurent; el Kheir, Musa; Bucheton, Bruno; Mary, Charles; El-Safi, Sayda Hassan; Dessein, Alain
- Abstract
IL-17 and IL-22 have been shown to increase protection against certain bacteria and fungal pathogens in experimental models. However, no human studies have demonstrated a crucial role of IL-17 and IL-22 in protection against infections. We show here that Leishmania donovani, which can cause the lethal visceral disease Kala Azar (KA), stimulates the differentiation of Th17 cells, which produce IL-17, IL-22, and IFN-gamma. Analysis of Th1, Th2, and Th17 cytokine responses by cultured PBMCs from individuals in a cohort of subjects who developed KA or were protected against KA during a severe outbreak showed that IL-17 and IL-22 were strongly and independently associated with protection against KA. Our results suggest that, along with Th1 cytokines, IL-17 and IL-22 play complementary roles in human protection against KA, and that a defect in Th17 induction may increase the risk of KA.
- Publication
The Journal of clinical investigation, 2009, Vol 119, Issue 8, p2379
- ISSN
1558-8238
- Publication type
Journal Article
- DOI
10.1172/JCI38813