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- Title
Evidence that cytokines play a role in rheumatoid arthritis.
- Authors
Brennan, Fionula M; McInnes, Iain B
- Abstract
A large number of cytokines are active in the joints of patients with rheumatoid arthritis (RA). It is now clear that these cytokines play a fundamental role in the processes that cause inflammation, articular destruction, and the comorbidities associated with RA. Following the success of TNF-alpha blockade as a treatment for RA, other cytokines now offer alternative targets for therapeutic intervention or might be useful as predictive biomarkers of disease. In this Review, we discuss the biologic contribution and therapeutic potential of the major cytokine families to RA pathology, focusing on molecules contained within the TNF-alpha, IL-1, IL-6, IL-23, and IL-2 families.
- Publication
The Journal of clinical investigation, 2008, Vol 118, Issue 11, p3537
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI36389