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- Title
Building bone to reverse osteoporosis and repair fractures.
- Authors
Khosla, Sundeep; Westendorf, Jennifer J; Oursler, Merry Jo
- Abstract
An important, unfilled clinical need is the development of new approaches to improve fracture healing and to treat osteoporosis by increasing bone mass. Recombinant forms of bone morphogenetic protein 2 (BMP2) and BMP7 are FDA approved to promote spinal fusion and fracture healing, respectively, and the first FDA-approved anabolic drug for osteoporosis, parathyroid hormone, increases bone mass when administered intermittently but can only be given to patients in the US for two years. As we discuss here, the tremendous explosion over the last two decades in our fundamental understanding of the mechanisms of bone remodeling has led to the prospect of mechanism-based anabolic therapies for bone disorders.
- Publication
The Journal of clinical investigation, 2008, Vol 118, Issue 2, p421
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI33612