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- Title
MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets.
- Authors
van Rooij, Eva; Olson, Eric N
- Abstract
MicroRNAs act as negative regulators of gene expression by inhibiting the translation or promoting the degradation of target mRNAs. Recent studies have revealed key roles of microRNAs as regulators of the growth, development, function, and stress responsiveness of the heart, providing glimpses of undiscovered regulatory mechanisms and potential therapeutic targets for the treatment of heart disease.
- Publication
The Journal of clinical investigation, 2007, Vol 117, Issue 9, p2369
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI33099