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- Title
Adoptive T cell therapy for cancer in the clinic.
- Authors
June, Carl H
- Abstract
The transfusion of lymphocytes, referred to as adoptive T cell therapy, is being tested for the treatment of cancer and chronic infections. Adoptive T cell therapy has the potential to enhance antitumor immunity, augment vaccine efficacy, and limit graft-versus-host disease. This form of personalized medicine is now in various early- and late-stage clinical trials. These trials are currently testing strategies to infuse tumor-infiltrating lymphocytes, CTLs, Th cells, and Tregs. Improved molecular biology techniques have also increased enthusiasm and feasibility for testing genetically engineered T cells. The current status of the field and prospects for clinical translation are reviewed herein.
- Publication
The Journal of clinical investigation, 2007, Vol 117, Issue 6, p1466
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI32446