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- Title
Cellular and molecular basis of wound healing in diabetes.
- Authors
Brem, Harold; Tomic-Canic, Marjana
- Abstract
Diabetic foot ulcers (DFUs), a leading cause of amputations, affect 15% of people with diabetes. A series of multiple mechanisms, including decreased cell and growth factor response, lead to diminished peripheral blood flow and decreased local angiogenesis, all of which can contribute to lack of healing in persons with DFUs. In this issue of the JCI, Gallagher and colleagues demonstrate that in diabetic mice, hyperoxia enhances the mobilization of circulating endothelial progenitor cells (EPCs) from the bone marrow to the peripheral circulation (see the related article beginning on page 1249). Local injection of the chemokine stromal cell-derived factor-1alpha then recruits these EPCs to the cutaneous wound site, resulting in accelerated wound healing. Thus, Gallagher et al. have identified novel potential targets for therapeutic intervention in diabetic wound healing.
- Publication
The Journal of clinical investigation, 2007, Vol 117, Issue 5, p1219
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI32169