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- Title
Discovery of the Philadelphia chromosome: a personal perspective.
- Authors
Nowell, Peter C
- Abstract
Almost 50 years ago, David Hungerford and I noticed an abnormally small chromosome in cells from patients with chronic myelogenous leukemia (CML). This article is a personal perspective of the events leading to the discovery of this chromosome, which became known as the Philadelphia chromosome. As technology advanced over subsequent decades, the translocation resulting in the Philadelphia chromosome has been identified, its role in the development of CML has been confirmed, and a therapy directed against the abnormal protein it produces has shown promising results in the treatment of patients with CML.
- Publication
The Journal of clinical investigation, 2007, Vol 117, Issue 8, p2033
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI31771