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- Title
An intrinsic host defense against HIV-1 integration?
- Authors
Bieniasz, Paul D
- Abstract
HSCs are one of only a few cell types that resist HIV-1 infection despite the presence of HIV-1 receptors. An increasing number of genes have been identified that can reduce the sensitivity of cultured cells to retrovirus infection, and in this issue of the JCI, Zhang et al. identify p21(Waf1/Cip1/Sdi1) (p21) as a gene product that can influence the sensitivity of HSCs to HIV-1 infection (see the related article beginning on page 473). Strikingly, p21 appears to alter the fate of nuclear HIV-1 DNA, promoting the formation of circular viral DNA forms rather than functional proviruses.
- Publication
The Journal of clinical investigation, 2007, Vol 117, Issue 2, p302
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI31290