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- Title
Macrophage heterogeneity and tissue lipids.
- Authors
Gordon, Siamon
- Abstract
Macrophages are present as resident cells in adipose tissue, and blood monocytes are recruited in increased numbers to sites of lipid accumulation in atherosclerosis, a modified form of inflammation in the arterial wall. Recent findings reported by 3 separate groups in this issue of the JCI provide evidence for distinct monocyte subsets, differential chemokine receptor usage, and phenotypic modulation of macrophages in murine models of genetic and high-fat diet-induced disease (see the related articles beginning on pages 175, 185, and 195). These studies raise prospects for selective therapeutic targets to ameliorate macrophage hyperinflammatory responses, while sparing host defense and repair mechanisms.
- Publication
The Journal of clinical investigation, 2007, Vol 117, Issue 1, p89
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI30992