We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Infectious disease, the innate immune response, and fibrosis.
- Authors
Meneghin, Alessia; Hogaboam, Cory M
- Abstract
The unrelenting and destructive progression of most fibrotic responses in the pulmonary, cardiovascular, integumentary, and alimentary systems remains a major medical challenge for which therapies are desperately needed. The pathophysiology of fibrosis remains an enigma, but considerable research and debate surrounds the question of whether chronic inflammation is the key driver of unrestrained wound healing (i.e., the fibrotic response) in these and other organ systems. This Review describes how infectious pathogens, chronic inflammation, and unrestrained fibroproliferation are likely to be part of a dynamic, unrelenting process propelling human fibrotic diseases.
- Publication
The Journal of clinical investigation, 2007, Vol 117, Issue 3, p530
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI30595