We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Deiodinases: implications of the local control of thyroid hormone action.
- Authors
Bianco, Antonio C; Kim, Brian W
- Abstract
The deiodinases activate or inactivate thyroid hormone, and their importance in thyroid hormone homeostasis has become increasingly clear with the availability of deiodinase-deficient animals. At the same time, heightened interest in the field has been generated following the discovery that the type 2 deiodinase can be an important component in both the Hedgehog signaling pathway and the G protein-coupled bile acid receptor 1-mediated (GPBAR1-mediated) signaling cascade. The discovery of these new roles for the deiodinases indicates that tissue-specific deiodination plays a much broader role than once thought, extending into the realms of developmental biology and metabolism.
- Publication
The Journal of clinical investigation, 2006, Vol 116, Issue 10, p2571
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI29812