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- Title
Inflamed fat: what starts the fire?
- Authors
Neels, Jaap G; Olefsky, Jerrold M
- Abstract
Obesity is associated with increased macrophage infiltration of adipose tissue, and these macrophages may be an important component of the chronic inflammatory response playing a crucial role in the development of insulin resistance. This prompts the question as to how macrophages infiltrate obese adipose tissue. In this issue of the JCI, Weisberg et al. show the importance of C-C motif chemokine receptor 2 (CCR2) in macrophage recruitment to adipose tissue and the development of obesity and its complications.
- Publication
The Journal of clinical investigation, 2006, Vol 116, Issue 1, p33
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI27280