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- Title
Structure and function of the platelet integrin alphaIIbbeta3.
- Authors
Bennett, Joel S
- Abstract
The platelet integrin alpha(IIb)beta(3) is required for platelet aggregation. Like other integrins, alpha(IIb)beta(3) resides on cell surfaces in an equilibrium between inactive and active conformations. Recent experiments suggest that the shift between these conformations involves a global reorganization of the alpha(IIb)beta(3) molecule and disruption of constraints imposed by the heteromeric association of the alpha(IIb) and beta(3) transmembrane and cytoplasmic domains. The biochemical, biophysical, and ultrastructural results that support this conclusion are discussed in this Review.
- Publication
The Journal of clinical investigation, 2005, Vol 115, Issue 12, p3363
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI26989