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- Title
IKK/NF-B signaling: balancing life and death - a new approach to cancer therapy.
- Authors
Jun-Li Luo; Kamata, Hideaki; Karin, Michael
- Abstract
IB kinase/NF-B (IKK/NF-B) signaling pathways play critical roles in a variety of physiological and pathological processes. One function of NF-B is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-B can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin, use NF-B to achieve resistance to anticancer drugs, radiation, and death cytokines. Hence, inhibition of IKK-driven NF-B activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression.
- Publication
Journal of Clinical Investigation, 2005, Vol 115, Issue 10, p2625
- ISSN
0021-9738
- Publication type
Academic Journal
- DOI
10.1172/JCI26322