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- Title
Mapping the new frontier: complex genetic disorders.
- Authors
Mayeux, Richard
- Abstract
The remarkable achievements in human genetics over the years have been due to technological advances in gene mapping and in statistical methods that relate genetic variants to disease. Nearly every Mendelian genetic disorder has now been mapped to a specific gene or set of genes, but these discoveries have been limited to high-risk, variant alleles that segregate in rare families. With a working draft of the human genome now in hand, the availability of high-throughput genotyping, a plethora of genetic markers, and the development of new analytical methods, scientists are now turning their attention to common complex disorders such as diabetes, obesity, hypertension, and Alzheimer disease. In this issue, the JCI provides readers with a series dedicated to complex genetic disorders, offering a view of genetic medicine in the 21st century.
- Publication
The Journal of clinical investigation, 2005, Vol 115, Issue 6, p1404
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI25421