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- Title
NO/redox disequilibrium in the failing heart and cardiovascular system.
- Authors
Hare, Joshua M; Stamler, Jonathan S
- Abstract
There is growing evidence that the altered production and/or spatiotemporal distribution of reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the failing heart and vascular tree, which contribute to the abnormal cardiac and vascular phenotypes that characterize the failing cardiovascular system. These derangements at the integrated system level can be interpreted at the cellular and molecular levels in terms of adverse effects on signaling elements in the heart, vasculature, and blood that subserve cardiac and vascular homeostasis.
- Publication
The Journal of clinical investigation, 2005, Vol 115, Issue 3, p509
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI24459