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- Title
A new mechanism of BRAF activation in human thyroid papillary carcinomas.
- Authors
Fusco, Alfredo; Viglietto, Giuseppe; Santoro, Massimo
- Abstract
In this issue of the JCI, Ciampi et al. report the identification of a novel oncogene in patients affected by radiation-associated thyroid papillary carcinomas. This oncogene derives from a paracentric inversion of the long arm of chromosome 7, which results in an in-frame fusion of the N-terminus of the A-kinase anchor protein 9 (AKAP9) gene with the C-terminal catalytic domain (exons 9-18) of the serine-threonine kinase BRAF. The resulting AKAP9-BRAF fusion protein shows constitutive kinase activity, and it is able to transmit mitogenic signals to the MAPK pathways and to promote malignant transformation of NIH3T3 cells.
- Publication
The Journal of clinical investigation, 2005, Vol 115, Issue 1, p20
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI23987