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- Title
HIF-1alpha expression regulates the bactericidal capacity of phagocytes.
- Authors
Peyssonnaux, Carole; Datta, Vivekanand; Cramer, Thorsten; Doedens, Andrew; Theodorakis, Emmanuel A; Gallo, Richard L; Hurtado-Ziola, Nancy; Nizet, Victor; Johnson, Randall S
- Abstract
Hypoxia is a characteristic feature of the tissue microenvironment during bacterial infection. Here we report on our use of conditional gene targeting to examine the contribution of hypoxia-inducible factor 1, alpha subunit (HIF-1alpha) to myeloid cell innate immune function. HIF-1alpha was induced by bacterial infection, even under normoxia, and regulated the production of key immune effector molecules, including granule proteases, antimicrobial peptides, nitric oxide, and TNF-alpha. Mice lacking HIF-1alpha in their myeloid cell lineage showed decreased bactericidal activity and failed to restrict systemic spread of infection from an initial tissue focus. Conversely, activation of the HIF-1alpha pathway through deletion of von Hippel-Lindau tumor-suppressor protein or pharmacologic inducers supported myeloid cell production of defense factors and improved bactericidal capacity. HIF-1alpha control of myeloid cell activity in infected tissues could represent a novel therapeutic target for enhancing host defense.
- Publication
The Journal of clinical investigation, 2005, Vol 115, Issue 7, p1806
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI23865