We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus.
- Authors
Chauvet, Veronique; Tian, Xin; Husson, Herve; Grimm, David H; Wang, Tong; Hiesberger, Thomas; Igarashi, Peter; Bennett, Anton M; Ibraghimov-Beskrovnaya, Oxana; Somlo, Stefan; Caplan, Michael J
- Abstract
Polycystin-1, which is encoded by a gene that is mutated in autosomal dominant polycystic kidney disease (ADPKD), is involved in cell-matrix interactions as well as in ciliary signaling. The precise mechanisms by which it functions, however, remain unclear. Here we find that polycystin-1 undergoes a proteolytic cleavage that releases its C-terminal tail (CTT), which enters the nucleus and initiates signaling processes. The cleavage occurs in vivo in association with alterations in mechanical stimuli. Polycystin-2, the product of the second gene mutated in ADPKD, modulates the signaling properties of the polycystin-1 CTT. These data reveal a novel pathway by which polycystin-1 transmits messages directly to the nucleus.
- Publication
The Journal of clinical investigation, 2004, Vol 114, Issue 10, p1433
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI21753