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- Title
Dengue: defining protective versus pathologic immunity.
- Authors
Rothman, Alan L
- Abstract
Dengue is an expanding public health problem, and an effective vaccine remains elusive. This review discusses how the significant influence of sequential infection with different dengue virus serotypes on the severity of disease can be viewed in terms of beneficial and detrimental effects of heterologous immunity. A more complete understanding of these effects is likely to be critical for predicting optimal vaccine-induced immune responses.
- Publication
The Journal of clinical investigation, 2004, Vol 113, Issue 7, p946
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI21512