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- Title
Bateman domains and adenosine derivatives form a binding contract.
- Authors
Kemp, Bruce E
- Abstract
Conserved pairs of CBS sequence motifs (named after cystathionine beta-synthase) found in a wide variety of proteins associate to form Bateman domains. A new study establishes that Bateman domains bind adenosyl compounds and regulate IMP dehydrogenase, CBS, chloride channels, and AMP-activated protein kinase. This discovery reveals how mutations in CBS sequences in these proteins cause hereditary diseases and provides a rich vista of conceptual opportunities for therapies in energy metabolism, obesity, diabetes, cancer, antivirals, and immunosuppression.
- Publication
The Journal of clinical investigation, 2004, Vol 113, Issue 2, p182
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI20846