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- Title
Epithelial-mesenchymal transition and its implications for fibrosis.
- Authors
Kalluri, Raghu; Neilson, Eric G
- Abstract
Epithelial to mesenchymal transition (EMT) is a central mechanism for diversifying the cells found in complex tissues. This dynamic process helps organize the formation of the body plan, and while EMT is well studied in the context of embryonic development, it also plays a role in the genesis of fibroblasts during organ fibrosis in adult tissues. Emerging evidence from studies of renal fibrosis suggests that more than a third of all disease-related fibroblasts originate from tubular epithelia at the site of injury. This review highlights recent advances in the process of EMT signaling in health and disease and how it may be attenuated or reversed by selective cytokines and growth factors.
- Publication
The Journal of clinical investigation, 2003, Vol 112, Issue 12, p1776
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI20530