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- Title
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
- Authors
Xuan, Shouhong; Kitamura, Tadahiro; Nakae, Jun; Politi, Katerina; Kido, Yoshiaki; Fisher, Peter E; Morroni, Manrico; Cinti, Saverio; White, Morris F; Herrera, Pedro L; Accili, Domenico; Efstratiadis, Argiris
- Abstract
Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases. In this regard, we sought to examine the potential proliferative and/or antiapoptotic role of IGFs in beta cells by tissue-specific conditional mutagenesis ablating type 1 IGF receptor (IGF1R) signaling. Unexpectedly, lack of functional IGF1R did not affect beta cell mass, but resulted in age-dependent impairment of glucose tolerance, associated with a decrease of glucose- and arginine-dependent insulin release. These observations reveal a requirement of IGF1R-mediated signaling for insulin secretion.
- Publication
The Journal of clinical investigation, 2002, Vol 110, Issue 7, p1011
- ISSN
0021-9738
- Publication type
Journal Article
- DOI
10.1172/JCI15276