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- Title
Bacillus Calmette-Guérin and isoniazid preventive therapy protect contacts of patients with tuberculosis.
- Authors
Zelner, Jonathan L; Murray, Megan B; Becerra, Mercedes C; Galea, Jerome; Lecca, Leonid; Calderon, Roger; Yataco, Rosa; Contreras, Carmen; Zhang, Zibiao; Grenfell, Bryan T; Cohen, Ted
- Abstract
Individuals living with patients with tuberculosis (TB) are at elevated risk of infection and disease, with children at greatest risk. The World Health Organization recommends isoniazid preventive therapy (IPT) for HIV-positive contacts and those younger than 5 years. Despite these recommendations, household-level IPT programs are rarely implemented in high TB burden settings. Evidence is scarce about the age-specific efficacy of interventions, such as IPT and bacillus Calmette-Guérin (BCG) vaccination for preventing TB disease among exposed contacts.
- Publication
American journal of respiratory and critical care medicine, 2014, Vol 189, Issue 7, p853
- ISSN
1535-4970
- Publication type
Journal Article
- DOI
10.1164/rccm.201310-1896OC