We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Influence of cross-linking degree of a biodegradable genipin-cross-linked gelatin guide on peripheral nerve regeneration.
- Authors
Lu, Ming-Chin; Hsiang, Shih-Wei; Lai, Tung-Yuan; Yao, Chun-Hsu; Lin, Li-Yu; Chen, Yueh-Sheng
- Abstract
We evaluated peripheral nerve regeneration using biodegradable genipin-cross-linked gelatin nerve conduits (GGCs) with three different cross-linking degrees, 24, 36 and 51%. Biocompatibility and biodegradability of the GGC and its efficiency as a guidance channel were examined based on the repair process of a 10-mm gap in the rat sciatic nerve. From this pilot study we concluded that GGCs with a mean cross-linking degree of 36% can ensure nerve regeneration with a more mature structure, as demonstrated by better developed epineural and perineural organisation and axonal development, as well as better-recovered electrophysiology with a relatively positive sciatic functional index and a shorter latency of the muscle action potential curve. Regenerated nerves in the GGCs with mean cross-linking degrees of 24 and 51% were less favourable, due to irritation caused by degradation material and compression by the remaining tube walls, respectively.
- Publication
Journal of biomaterials science. Polymer edition, 2007, Vol 18, Issue 7, p843
- ISSN
0920-5063
- Publication type
Journal Article
- DOI
10.1163/156856207781367747