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- Title
Assessment of hippocampal adeno-associated viral vector gene delivery via frameless stereotaxis in a nonhuman primate.
- Authors
Leung, Cary H; Kliem, Michele A; Heeke, Brenten L; McPhee, Scott W J; Federici, Thais; Snyder, Brooke R; Boulis, Nicholas M
- Abstract
Expression of the neuropeptide galanin in hippocampal neurons reduces seizures in the kainic acid rodent model of epilepsy. In order to translate these findings into a human clinical trial, the safety and feasibility of hippocampal adeno-associated viral (AAV) vector expression must be demonstrated in a nonhuman primate model.
- Publication
Stereotactic and functional neurosurgery, 2011, Vol 89, Issue 5, p275
- ISSN
1423-0372
- Publication type
Journal Article
- DOI
10.1159/000328265