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- Title
A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease.
- Authors
Burns, Alistair; Perry, Elaine; Holmes, Clive; Francis, Paul; Morris, Julie; Howes, Melanie-Jayne R; Chazot, Paul; Lees, George; Ballard, Clive
- Abstract
Behavioural and psychological symptoms (BPSD) are frequent in people with Alzheimer's disease and cause considerable stress to patients and their carers. Antipsychotics have been widely used as a first-line treatment, resulting in an estimated 1,800 excess strokes and 1,600 excess deaths in the UK alone. Safe and effective alternatives are urgently needed. Based upon preliminary evidence from clinical trials, aromatherapy with melissa oil may be such an alternative, but initial studies have been modest in size, and adequate blinding has been problematic. Our objective was to assess the efficacy of melissa aromatherapy in the treatment of agitation in people with Alzheimer's disease in an adequately powered and robustly blinded randomized controlled trial comparing it with donepezil, an anticholinesterase drug used with some benefit to treat BPSD.
- Publication
Dementia and geriatric cognitive disorders, 2011, Vol 31, Issue 2, p158
- ISSN
1421-9824
- Publication type
Journal Article
- DOI
10.1159/000324438