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- Title
Chronic obstructive pulmonary disease-specific gene expression signatures of alveolar macrophages as well as peripheral blood monocytes overlap and correlate with lung function.
- Authors
Poliska, Szilard; Csanky, Eszter; Szanto, Attila; Szatmari, Istvan; Mesko, Bertalan; Szeles, Lajos; Dezso, Balazs; Scholtz, Beata; Podani, Janos; Kilty, Iain; Takacs, Laszlo; Nagy, Laszlo
- Abstract
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by progressive airflow limitation and significant extrapulmonary (systemic) effects that lead to co-morbid conditions, though the pathomechanism of COPD is largely undetermined. Alveolar macrophages (AM) derived from peripheral monocytes (MO) appear to play a key role in initiating and/or sustaining disease progression.
- Publication
Respiration; international review of thoracic diseases, 2011, Vol 81, Issue 6, p499
- ISSN
1423-0356
- Publication type
Journal Article
- DOI
10.1159/000324297