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- Title
Sensitivity of chloride efflux vs. transepithelial measurements in mixed CF and normal airway epithelial cell populations.
- Authors
Illek, Beate; Lei, Dachuan; Fischer, Horst; Gruenert, Dieter C
- Abstract
While the Cl(-) efflux assays are relatively straightforward, their ability to assess the efficacy of phenotypic correction in cystic fibrosis (CF) tissue or cells may be limited. Accurate assessment of therapeutic efficacy, i.e., correlating wild type CF transmembrane conductance regulator (CFTR) levels with phenotypic correction in tissue or individual cells, requires a sensitive assay.
- Publication
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010, Vol 26, Issue 6, p983
- ISSN
1421-9778
- Publication type
Journal Article
- DOI
10.1159/000324011