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- Title
Novel platform for MRI-guided convection-enhanced delivery of therapeutics: preclinical validation in nonhuman primate brain.
- Authors
Richardson, R Mark; Kells, Adrian P; Martin, Alastair J; Larson, Paul S; Starr, Philip A; Piferi, Peter G; Bates, Geoffrey; Tansey, Lisa; Rosenbluth, Kathryn H; Bringas, John R; Berger, Mitchel S; Bankiewicz, Krystof S
- Abstract
A skull-mounted aiming device and integrated software platform has been developed for MRI-guided neurological interventions. In anticipation of upcoming gene therapy clinical trials, we adapted this device for real-time convection-enhanced delivery of therapeutics via a custom-designed infusion cannula. The targeting accuracy of this delivery system and the performance of the infusion cannula were validated in nonhuman primates.
- Publication
Stereotactic and functional neurosurgery, 2011, Vol 89, Issue 3, p141
- ISSN
1423-0372
- Publication type
Journal Article
- DOI
10.1159/000323544