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- Title
The progressive ankylosis protein regulates cementum apposition and extracellular matrix composition.
- Authors
Foster, B L; Nagatomo, K J; Bamashmous, S O; Tompkins, K A; Fong, H; Dunn, D; Chu, E Y; Guenther, C; Kingsley, D M; Rutherford, R B; Somerman, M J
- Abstract
Tooth root cementum is sensitive to modulation of inorganic pyrophosphate (PP(i)), an inhibitor of hydroxyapatite precipitation. Factors increasing PP(i) include progressive ankylosis protein (ANK) and ectonucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) while tissue nonspecific alkaline phosphatase hydrolyzes PP(i). Studies here aimed to define the role of ANK in root and cementum by analyzing tooth development in Ank knock-out (KO) mice versus wild type.
- Publication
Cells, tissues, organs, 2011, Vol 194, Issue 5, p382
- ISSN
1422-6421
- Publication type
Journal Article
- DOI
10.1159/000323457