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- Title
Angiopoietin-like 4 (ANGPTL4) gene polymorphisms and risk of brain arteriovenous malformations.
- Authors
Mikhak, Bahar; Weinsheimer, Shantel; Pawlikowska, Ludmila; Poon, Annie; Kwok, Pui-Yan; Lawton, Michael T; Chen, Yongmei; Zaroff, Jonathan G; Sidney, Stephen; McCulloch, Charles E; Young, William L; Kim, Helen
- Abstract
Brain arteriovenous malformations (BAVM) are high-flow vascular lesions prone to intracranial hemorrhage (ICH). Abnormal angiogenesis is a key characteristic of BAVM tissue. Angiopoietin-like 4 (ANGPTL4), a secreted glycoprotein, is thought to be involved in angiogenesis and required for proper postnatal blood vessel partitioning. We investigated whether common single nucleotide polymorphisms (SNPs) in ANGPTL4 were associated with risk of BAVM or ICH.
- Publication
Cerebrovascular diseases (Basel, Switzerland), 2011, Vol 31, Issue 4, p338
- ISSN
1421-9786
- Publication type
Journal Article
- DOI
10.1159/000322601