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- Title
Marfan syndrome decreases Ca2+ wave frequency and vasoconstriction in murine mesenteric resistance arteries without changing underlying mechanisms.
- Authors
Syyong, H T; Chung, A W Y; van Breemen, C
- Abstract
Vascular smooth muscle in Marfan syndrome, a connective tissue disorder caused by mutations in FBN1 encoding fibrillin-1, is associated with decreased tonic contraction. As Ca(2+) waves are tightly associated with vasoconstriction, we hypothesized decreased tonic contraction in Marfan syndrome is due to aberrant Ca(2+) wave signaling.
- Publication
Journal of vascular research, 2011, Vol 48, Issue 2, p150
- ISSN
1423-0135
- Publication type
Journal Article
- DOI
10.1159/000318804