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- Title
Cannabinoids inhibit cellular respiration of human oral cancer cells.
- Authors
Whyte, Donna A; Al-Hammadi, Suleiman; Balhaj, Ghazala; Brown, Oliver M; Penefsky, Harvey S; Souid, Abdul-Kader
- Abstract
The primary cannabinoids, Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and Delta(8)-tetrahydrocannabinol (Delta(8)-THC) are known to disturb the mitochondrial function and possess antitumor activities. These observations prompted us to investigate their effects on the mitochondrial O(2) consumption in human oral cancer cells (Tu183). This epithelial cell line overexpresses bcl-2 and is highly resistant to anticancer drugs.
- Publication
Pharmacology, 2010, Vol 85, Issue 6, p328
- ISSN
1423-0313
- Publication type
Journal Article
- DOI
10.1159/000312686