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Title
Neuroinflammation - an early event in both the history and pathogenesis of Alzheimer's disease.
Authors
Eikelenboom, Piet; van Exel, Erik; Hoozemans, Jeroen J M; Veerhuis, Rob; Rozemuller, Annemieke J M; van Gool, Willem A
Abstract
About hundred years ago, Oskar Fischer proposed that the senile plaques are the consequence of the deposition of a foreign substance that could induce an inflammatory response leading to an abnormal neuritic response of the surrounding neurons.