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- Title
Inhibition of protein kinase CK2 closes the CFTR Cl channel, but has no effect on the cystic fibrosis mutant deltaF508-CFTR.
- Authors
Treharne, Kate J; Xu, Zhe; Chen, Jeng-Haur; Best, O Giles; Cassidy, Diane M; Gruenert, Dieter C; Hegyi, Péter; Gray, Michael A; Sheppard, David N; Kunzelmann, Karl; Mehta, Anil
- Abstract
Deletion of phenylalanine-508 (DeltaF508) from the first nucleotide-binding domain (NBD1) in the wild-type cystic fibrosis (CF) transmembrane-conductance regulator (wtCFTR) causes CF. However, the mechanistic relationship between DeltaF508-CFTR and the diversity of CF disease is unexplained. The surface location of F508 on NBD1 creates the potential for protein-protein interactions and nearby, lies a consensus sequence (SYDE) reported to control the pleiotropic protein kinase CK2.
- Publication
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2009, Vol 24, Issue 5-6, p347
- ISSN
1421-9778
- Publication type
Journal Article
- DOI
10.1159/000257427