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- Title
Large vessel cerebral atherosclerosis is not in direct association with neuropathological lesions of Alzheimer's disease.
- Authors
Luoto, Teemu M; Haikonen, Satu; Haapasalo, Hannu; Goebeler, Sirkka; Huhtala, Heini; Erkinjuntti, Timo; Karhunen, Pekka J
- Abstract
Cerebral hypoperfusion caused by large vessel atherosclerosis has been suggested to be associated with the pathogenesis of sporadic Alzheimer's disease (AD). Atherosclerosis and AD share risk factors such as age, diabetes, hypercholesterolemia, hypertension and apolipoprotein E epsilon4 (APOE epsilon4) allele. We studied the association between atherosclerosis of the circle of Willis (CW) and AD neuropathology in a large autopsy sample.
- Publication
European neurology, 2009, Vol 62, Issue 2, p93
- ISSN
1421-9913
- Publication type
Journal Article
- DOI
10.1159/000222779