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- Title
Neutrophilic inflammation and CXC chemokines in patients with refractory asthma.
- Authors
Kikuchi, Shinya; Kikuchi, Izumi; Takaku, Yotaro; Kobayashi, Takehito; Hagiwara, Koichi; Kanazawa, Minoru; Nagata, Makoto
- Abstract
There is evidence that eosinophils and neutrophils are simultaneously increased in the airways of some patients with chronic refractory asthma. The mechanisms by which neutrophils accumulate in the airways of asthmatics remain to be elucidated, however, chemoattractants for neutrophils such as CXC chemokines may affect either the accumulation or functional status of neutrophils in such patients. The objective of the present study was to identify the CXC chemokine responsible for the neutrophilic and possibly eosinophilic inflammation observed in the airways of patients with refractory asthma.
- Publication
International archives of allergy and immunology, 2009, Vol 149 Suppl 1, p87
- ISSN
1423-0097
- Publication type
Journal Article
- DOI
10.1159/000211379