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- Title
Association of a 5-HT1Dβ Receptor Gene Polymorphism with Obsessive-Compulsive Disorder in Korean Male Subjects.
- Authors
Se Joo Kim; Kee Namkoong; Jee In Kang; Chan-Hyung Kim
- Abstract
The 5-HT1Dβ receptor gene appears to be particularly interesting in the pathophysiology of obsessive-compulsive disorder (OCD). The 5-HT1Dβ receptor is a terminal autoreceptor involved in the regulation of serotonin synthesis and release. We performed an association study of the G861C single nucleotide polymorphism (SNP) of the 5-HT1Dβ receptor in 167 male Korean OCD subjects and in 107 controls. Individuals with the G allele had an increased chance of having OCD (OR 1.49, 95% CI 1.05–2.10). Our findings suggest an association between the G861C SNP of the 5-HT1Dβ receptor and males with OCD. In the future, other tag SNPs that cover the entire 5-HT1Dβ gene region as well as additional SNPs that are supposed to have meaningful functions should be investigated in both male and female OCD subjects. Copyright © 2009 S. Karger AG, Basel
- Publication
Neuropsychobiology, 2009, Vol 59, Issue 2, p96
- ISSN
0302-282X
- Publication type
Academic Journal
- DOI
10.1159/000209861