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- Title
ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells.
- Authors
Hagmann, Wolfgang; Jesnowski, Ralf; Faissner, Ralf; Guo, Changqing; Löhr, J Matthias
- Abstract
Pancreatic cancer is characterized by high resistance to chemotherapy. Such chemoresistance can be mediated by multidrug resistance proteins (MRPs), breast cancer resistance protein (BCRP), and MDR1 P-glycoprotein. However, the contribution of individual MRP isoforms to chemoresistance in pancreatic carcinoma is unclear. We studied ATP-binding cassette (ABC) transporter expression in human pancreatic carcinoma cell lines as compared to primary pancreatic duct cells, and analyzed the MRP expression profile in 5-fluorouracil-resistant cells.
- Publication
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2009, Vol 9, Issue 1-2, p136
- ISSN
1424-3911
- Publication type
Journal Article
- DOI
10.1159/000178884