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- Title
Primary aldosteronism.
- Authors
Carey, Robert M
- Abstract
Hypertension is one of the world's leading risk factors for morbidity and mortality. Most affected individuals have primary hypertension, while the most common cause of secondary hypertension is primary aldosteronism (6-10%). PRIMARY ALDOSTERONISM: Clinical manifestations include hypertension, hypokalemic alkalosis, renal dysfunction, nephrogenic diabetes insipidus, muscle weakness, paresthesias, tetany and, in severe cases, paralysis. The cardiovascular risks for patients with primary aldosteronism are greater than those for patients with primary hypertension. Compared with normotensive subjects, patients with primary aldosteronism have a 4.2-fold greater risk of stroke, a 6.5-fold greater risk of myocardial infarction and a 12.1-fold greater risk of atrial fibrillation.
- Publication
Hormone research, 2009, Vol 71 Suppl 1, p8
- ISSN
1423-0046
- Publication type
Journal Article
- DOI
10.1159/000178029