We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Post-transplant lymphoproliferative disorders after heart or kidney transplantation at a single centre: presentation and response to treatment.
- Authors
Aversa, S M L; Stragliotto, S; Marino, D; Calabrese, F; Rigotti, P; Marchini, F; Gambino, A; Feltrin, G; Boso, C; Canova, F; Soldà, C; Mazzarotto, R; Burra, P
- Abstract
Post-transplant lymphoproliferative disorders (PTLD) is a serious complication after solid organ transplantation. Reduction of immunosuppression (RI) alone is not able to control the disease. We report a prospective analysis of 30 patients with PTLD after heart or kidney transplantation. Only 5 of 30 patients, treated solely with RI, obtained a complete response. Five patients were treated heterogeneously; in the remaining 20, the efficacy and safety of a weekly anthracycline-based chemotherapy were assessed. Sixteen patients obtained a complete remission. One death was related to treatment. With a median follow-up of 36 months, 3-year overall survival was 63.3% and 57% for the entire group and the chemotherapy-treated group, respectively. Moreover, 4 second neoplasms were observed in the chemotherapeutic group. In this study, we demonstrated that most PTLD need other treatment than RI and a weekly regimen is manageable and has a favourable impact on long-term survival.
- Publication
Acta haematologica, 2008, Vol 120, Issue 1, p36
- ISSN
1421-9662
- Publication type
Journal Article
- DOI
10.1159/000155234