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- Title
Racial differences in the influence of the APOE epsilon 4 allele on cognitive decline in a sample of community-dwelling older adults.
- Authors
Sawyer, Kathryn; Sachs-Ericsson, Natalie; Preacher, Kristopher J; Blazer, Dan G
- Abstract
Most, but not all, past studies have suggested that the APOE genotype is a risk factor for dementia in whites but not African Americans. This paper first describes explanations as to why some studies may have failed to detect the effect of APOE genotype in African American samples. Briefly, studies have been limited by various methodological problems including small sample sizes, dichotomous measures of cognitive functioning (which tend to be less sensitive to change), and racial bias in assessing demented status.
- Publication
Gerontology, 2009, Vol 55, Issue 1, p32
- ISSN
1423-0003
- Publication type
Journal Article
- DOI
10.1159/000137666